Milk Fat Globule-Epidermal Growth Factor-Factor 8 Reverses Lipopolysaccharide-Induced Microglial Oxidative Stress.
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SUBMITTER: Li J
PROVIDER: S-EPMC6436360 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
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Milk Fat Globule-Epidermal Growth Factor-Factor 8 Reverses Lipopolysaccharide-Induced Microglial Oxidative Stress.
Li Jie J Xu Xiaotian X Cai Xiaoying X Weng Yinlun Y Wang Yiping Y Shen Qingyu Q Shi Xiaolei X
Oxidative medicine and cellular longevity 20190313
Oxidative stress plays an important role in various neurological disorders. Milk fat globule-epidermal growth factor-factor 8 (MFG-E8) is a regulatory protein for microglia. However, its involvement in microglial oxidative stress has not been established. In this study, we observed microglial oxidative stress in response to lipopolysaccharide (LPS) both <i>in vitro</i> and <i>in vivo</i>. LPS induced significant elevation of TNF-<i>α</i>, IL-6, MDA, and ROS and reduction of GSH and SOD in the mo ...[more]
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