PI3 kinase signals BCR-dependent mature B cell survival.
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ABSTRACT:
SUBMITTER: Srinivasan L
PROVIDER: S-EPMC2787092 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Publications
PI3 kinase signals BCR-dependent mature B cell survival.
Srinivasan Lakshmi L Sasaki Yoshiteru Y Calado Dinis Pedro DP Zhang Baochun B Paik Ji Hye JH DePinho Ronald A RA Kutok Jeffrey L JL Kearney John F JF Otipoby Kevin L KL Rajewsky Klaus K
Cell 20091001 3
Previous work has shown that mature B cells depend upon survival signals delivered to the cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, we have developed a genetic approach in which ablation of the BCR is combined with the activation of specific, BCR dependent signaling cascades in mature B cells in vivo. Using this system, we provide evidence that the survival of BCR deficient mature B cells can be rescued by a single signaling pathway downstre ...[more]
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