Ontology highlight
ABSTRACT:
SUBMITTER: Hannum G
PROVIDER: S-EPMC2788232 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Hannum Gregory G Srivas Rohith R Guénolé Aude A van Attikum Haico H Krogan Nevan J NJ Karp Richard M RM Ideker Trey T
PLoS genetics 20091224 12
This work demonstrates how gene association studies can be analyzed to map a global landscape of genetic interactions among protein complexes and pathways. Despite the immense potential of gene association studies, they have been challenging to analyze because most traits are complex, involving the combined effect of mutations at many different genes. Due to lack of statistical power, only the strongest single markers are typically identified. Here, we present an integrative approach that greatl ...[more]