Ontology highlight
ABSTRACT:
SUBMITTER: Heidari N
PROVIDER: S-EPMC4248309 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Heidari Nastaran N Phanstiel Douglas H DH He Chao C Grubert Fabian F Jahanbani Fereshteh F Kasowski Maya M Zhang Michael Q MQ Snyder Michael P MP
Genome research 20140916 12
Increasing evidence suggests that interactions between regulatory genomic elements play an important role in regulating gene expression. We generated a genome-wide interaction map of regulatory elements in human cells (ENCODE tier 1 cells, K562, GM12878) using Chromatin Interaction Analysis by Paired-End Tag sequencing (ChIA-PET) experiments targeting six broadly distributed factors. Bound regions covered 80% of DNase I hypersensitive sites including 99.7% of TSS and 98% of enhancers. Correlatin ...[more]