Ontology highlight
ABSTRACT:
SUBMITTER: Khayrutdinov BI
PROVIDER: S-EPMC2788280 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Protein science : a publication of the Protein Society 20091101 11
In eukaryotic replication licensing, Cdt1 plays a key role by recruiting the MCM2-7 complex onto the origin of chromosome. The C-terminal domain of mouse Cdt1 (mCdt1C), the most conserved region in Cdt1, is essential for licensing and directly interacts with the MCM2-7 complex. We have determined the structures of mCdt1CS (mCdt1C_small; residues 452 to 557) and mCdt1CL (mCdt1C_large; residues 420 to 557) using X-ray crystallography and solution NMR spectroscopy, respectively. While the N-termina ...[more]