Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humans.
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ABSTRACT:
SUBMITTER: Salvadore G
PROVIDER: S-EPMC2788985 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
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Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humans.
Salvadore Giacomo G Nugent Allison C AC Chen Guang G Akula Nirmala N Yuan Peixiong P Cannon Dara M DM Zarate Carlos A CA McMahon Francis J FJ Manji Husseini K HK Drevets Wayne C WC
Biological psychiatry 20090709 8
<h4>Background</h4>Bcl-2 is a major regulator of neural plasticity and cellular resilience. A single nucleotide polymorphism (SNP) in the Bcl-2 gene, Bcl-2 rs956572, significantly modulates the expression of Bcl-2 protein and cellular vulnerability to apoptosis. We tested the hypothesis that this SNP would modulate gray matter (GM) volume in the limbic-cortical-striatal-pallidal-thalamic circuitry that plays major roles in mood regulation.<h4>Methods</h4>Forty-seven healthy subjects participated ...[more]
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