A single IGF1 allele is a major determinant of small size in dogs.
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ABSTRACT:
SUBMITTER: Sutter NB
PROVIDER: S-EPMC2789551 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Publications
A single IGF1 allele is a major determinant of small size in dogs.
Sutter Nathan B NB Bustamante Carlos D CD Chase Kevin K Gray Melissa M MM Zhao Keyan K Zhu Lan L Padhukasahasram Badri B Karlins Eric E Davis Sean S Jones Paul G PG Quignon Pascale P Johnson Gary S GS Parker Heidi G HG Fretwell Neale N Mosher Dana S DS Lawler Dennis F DF Satyaraj Ebenezer E Nordborg Magnus M Lark K Gordon KG Wayne Robert K RK Ostrander Elaine A EA
Science (New York, N.Y.) 20070401 5821
The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. We used a strategy that exploits the breed structure of dogs to investigate the genetic basis of size. First, through a genome-wide scan, we identified a major quantitative trait locus (QTL) on chromosome 15 influencing size variation within a single breed. Second, we examined genetic variation in the 15-megabase interval surrounding the QTL in small and giant breeds and found marked evidence for a se ...[more]
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