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GOAT links dietary lipids with the endocrine control of energy balance.

ABSTRACT: Central nervous system nutrient sensing and afferent endocrine signaling have been established as parallel systems communicating metabolic status and energy availability in vertebrates. The only afferent endocrine signal known to require modification with a fatty acid side chain is the orexigenic hormone ghrelin. We find that the ghrelin O-acyl transferase (GOAT), which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylation substrates and links ingested lipids to energy expenditure and body fat mass. These data implicate the ghrelin-GOAT system as a signaling pathway that alerts the central nervous system to the presence of dietary calories, rather than to their absence as is commonly accepted.

SUBMITTER: Kirchner H

PROVIDER: S-EPMC2789701 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature

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GOAT links dietary lipids with the endocrine control of energy balance.

Kirchner Henriette H Gutierrez Jesus A JA Solenberg Patricia J PJ Pfluger Paul T PT Czyzyk Traci A TA Willency Jill A JA Schürmann Annette A Joost Hans-Georg HG Jandacek Ronald J RJ Hale John E JE Heiman Mark L ML Tschöp Matthias H MH

Nature medicine 20090605 7

Central nervous system nutrient sensing and afferent endocrine signaling have been established as parallel systems communicating metabolic status and energy availability in vertebrates. The only afferent endocrine signal known to require modification with a fatty acid side chain is the orexigenic hormone ghrelin. We find that the ghrelin O-acyl transferase (GOAT), which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylation subs ...[more]

PMID: 19503064

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