Ontology highlight
ABSTRACT:
SUBMITTER: Castaneda TR
PROVIDER: S-EPMC3296718 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Castañeda Tamara R TR Abplanalp William W Um Sung Hee SH Pfluger Paul T PT Schrott Brigitte B Brown Kimberly K Grant Erin E Carnevalli Larissa L Benoit Stephen C SC Morgan Donald A DA Gilham Dean D Hui David Y DY Rahmouni Kamal K Thomas George G Kozma Sara C SC Clegg Deborah J DJ Tschöp Matthias H MH
PloS one 20120307 3
Targeted deletion of S6 kinase (S6K) 1 in mice leads to higher energy expenditure and improved glucose metabolism. However, the molecular mechanisms controlling these effects remain to be fully elucidated. Here, we analyze the potential role of dietary lipids in regulating the mTORC1/S6K system. Analysis of S6K phosphorylation in vivo and in vitro showed that dietary lipids activate S6K, and this effect is not dependent upon amino acids. Comparison of male mice lacking S6K1 and 2 (S6K-dko) with ...[more]