Unknown

Dataset Information

0

Yeast axial-element protein, Red1, binds SUMO chains to promote meiotic interhomologue recombination and chromosome synapsis.


ABSTRACT: The synaptonemal complex (SC) is a tripartite protein structure consisting of two parallel axial elements (AEs) and a central region. During meiosis, the SC connects paired homologous chromosomes, promoting interhomologue (IH) recombination. Here, we report that, like the CE component Zip1, Saccharomyces cerevisiae axial-element structural protein, Red1, can bind small ubiquitin-like modifier (SUMO) polymeric chains. The Red1-SUMO chain interaction is dispensable for the initiation of meiotic DNA recombination, but it is essential for Tel1- and Mec1-dependent Hop1 phosphorylation, which ensures IH recombination by preventing the inter-sister chromatid DNA repair pathway. Our results also indicate that Red1 and Zip1 may directly sandwich the SUMO chains to mediate SC assembly. We suggest that Red1 and SUMO chains function together to couple homologous recombination and Mec1-Tel1 kinase activation with chromosome synapsis during yeast meiosis.

SUBMITTER: Lin FM 

PROVIDER: S-EPMC2789940 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Yeast axial-element protein, Red1, binds SUMO chains to promote meiotic interhomologue recombination and chromosome synapsis.

Lin Feng-Ming FM   Lai Yi-Ju YJ   Shen Hui-Ju HJ   Cheng Yun-Hsin YH   Wang Ting-Fang TF  

The EMBO journal 20091203 3


The synaptonemal complex (SC) is a tripartite protein structure consisting of two parallel axial elements (AEs) and a central region. During meiosis, the SC connects paired homologous chromosomes, promoting interhomologue (IH) recombination. Here, we report that, like the CE component Zip1, Saccharomyces cerevisiae axial-element structural protein, Red1, can bind small ubiquitin-like modifier (SUMO) polymeric chains. The Red1-SUMO chain interaction is dispensable for the initiation of meiotic DN  ...[more]

Similar Datasets

| S-EPMC3067829 | biostudies-literature
| S-EPMC4435792 | biostudies-literature
| S-EPMC8896719 | biostudies-literature
| S-EPMC5549997 | biostudies-literature
| S-EPMC2926792 | biostudies-literature
| S-EPMC5569317 | biostudies-literature
| S-EPMC4565782 | biostudies-literature
| S-EPMC404073 | biostudies-literature
| S-EPMC3916230 | biostudies-literature
| S-EPMC3789832 | biostudies-literature