Ontology highlight
ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC404073 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Liu Lin L Franco Sonia S Spyropoulos Barbara B Moens Peter B PB Blasco Maria A MA Keefe David L DL
Proceedings of the National Academy of Sciences of the United States of America 20040414 17
Telomere shortening can lead to chromosome instability, replicative senescence, and apoptosis in both somatic and male germ cells. To study roles for mammalian telomeres in homologous pairing and recombination, we characterized effects of telomere shortening on spermatogenesis and oogenesis in late-generation telomerase-deficient mice. We show that shortened telomeres of late-generation telomerase-deficient mice impair meiotic synapsis and decrease recombination, in particular, in females. In re ...[more]