Ontology highlight
ABSTRACT:
SUBMITTER: Grubb RL
PROVIDER: S-EPMC2790378 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Grubb Robert L RL Deng Jianghong J Pinto Peter A PA Mohler James L JL Chinnaiyan Arul A Rubin Mark M Linehan W Marston WM Liotta Lance A LA Petricoin Emanuel F EF Wulfkuhle Julia D JD
Journal of proteome research 20090601 6
Reverse phase protein microarray technology was used to study key signaling pathways thought to be involved in the progression of benign epithelium to the lethal phenotype of prostate cancer. Specimens of androgen-stimulated localized prostate cancer (N = 21) and androgen-deprivation therapy-recurrent local (N = 4) or metastatic (N = 11) prostate cancer were laser capture microdissected prior to analysis. The results showed significant increases in protein expression levels in malignant epitheli ...[more]