Dataset Information

High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.

ABSTRACT: Genetics is a well-established but poorly understood determinant of BMD. Whereas some genetic variants may influence BMD throughout the body, others may be skeletal site specific. We initially screened for associations between 4608 tagging and potentially functional single nucleotide polymorphisms (SNPs) in 383 candidate genes and femoral neck and lumbar spine volumetric BMD (vBMD) measured from QCT scans among 862 community-dwelling white men >or=65 yr of age in the Osteoporotic Fractures in Men Study (MrOS). The most promising SNP associations (p < 0.01) were validated by genotyping an additional 1156 white men from MrOS. This analysis identified 8 SNPs in 6 genes (APC, DMP1, FGFR2, FLT1, HOXA, and PTN) that were associated with femoral neck vBMD and 13 SNPs in 7 genes (APC, BMPR1B, FOXC2, HOXA, IGFBP2, NFATC1, and SOST) that were associated with lumbar spine vBMD in both genotyping samples (p < 0.05). Although most associations were specific to one skeletal site, SNPs in the APC and HOXA gene regions were associated with both femoral neck and lumbar spine BMD. This analysis identifies several novel and robust genetic associations for volumetric BMD, and these findings in combination with other data suggest the presence of genetic loci for volumetric BMD that are at least to some extent skeletal-site specific.

SUBMITTER: Yerges LM

PROVIDER: S-EPMC2791518 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature

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High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.

Yerges Laura M LM Klei Lambertus L Cauley Jane A JA Roeder Kathryn K Kammerer Candace M CM Moffett Susan P SP Ensrud Kristine E KE Nestlerode Cara S CS Marshall Lynn M LM Hoffman Andrew R AR Lewis Cora C Lang Thomas F TF Barrett-Connor Elizabeth E Ferrell Robert E RE Orwoll Eric S ES Zmuda Joseph M JM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20091201 12

Genetics is a well-established but poorly understood determinant of BMD. Whereas some genetic variants may influence BMD throughout the body, others may be skeletal site specific. We initially screened for associations between 4608 tagging and potentially functional single nucleotide polymorphisms (SNPs) in 383 candidate genes and femoral neck and lumbar spine volumetric BMD (vBMD) measured from QCT scans among 862 community-dwelling white men >or=65 yr of age in the Osteoporotic Fractures in Me ...[more]

PMID: 19453261

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Dataset Information

High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.

Publications

High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.

Similar Datasets

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