Ontology highlight
ABSTRACT:
SUBMITTER: Kizhatil K
PROVIDER: S-EPMC2792576 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Kizhatil Krishnakumar K Baker Sheila A SA Arshavsky Vadim Y VY Bennett Vann V
Science (New York, N.Y.) 20090301 5921
Cyclic nucleotide-gated (CNG) channels localize exclusively to the plasma membrane of photosensitive outer segments of rod photoreceptors where they generate the electrical response to light. Here, we report the finding that targeting of CNG channels to the rod outer segment required their interaction with ankyrin-G. Ankyrin-G localized exclusively to rod outer segments, coimmunoprecipitated with the CNG channel, and bound to the C-terminal domain of the channel beta1 subunit. Ankyrin-G depletio ...[more]