Ontology highlight
ABSTRACT:
SUBMITTER: Igl W
PROVIDER: S-EPMC2792712 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Igl Wilmar W Johansson Asa A Wilson James F JF Wild Sarah H SH Polasek Ozren O Hayward Caroline C Vitart Veronique V Hastie Nicholas N Rudan Pavao P Gnewuch Carsten C Schmitz Gerd G Meitinger Thomas T Pramstaller Peter P PP Hicks Andrew A AA Oostra Ben A BA van Duijn Cornelia M CM Rudan Igor I Wright Alan A Campbell Harry H Gyllensten Ulf U
PLoS genetics 20100108 1
Genome-wide association studies (GWAS) have identified 38 larger genetic regions affecting classical blood lipid levels without adjusting for important environmental influences. We modeled diet and physical activity in a GWAS in order to identify novel loci affecting total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride levels. The Swedish (SE) EUROSPAN cohort (N(SE) = 656) was screened for candidate genes and the non-Swedish (NS) EUROSPAN cohorts (N(NS) = 3,282) were used for re ...[more]