Ontology highlight
ABSTRACT:
SUBMITTER: Kettunen J
PROVIDER: S-EPMC3605033 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Kettunen Johannes J Tukiainen Taru T Sarin Antti-Pekka AP Ortega-Alonso Alfredo A Tikkanen Emmi E Lyytikäinen Leo-Pekka LP Kangas Antti J AJ Soininen Pasi P Würtz Peter P Silander Kaisa K Dick Danielle M DM Rose Richard J RJ Savolainen Markku J MJ Viikari Jorma J Kähönen Mika M Lehtimäki Terho T Pietiläinen Kirsi H KH Inouye Michael M McCarthy Mark I MI Jula Antti A Eriksson Johan J Raitakari Olli T OT Salomaa Veikko V Kaprio Jaakko J Järvelin Marjo-Riitta MR Peltonen Leena L Perola Markus M Freimer Nelson B NB Ala-Korpela Mika M Palotie Aarno A Ripatti Samuli S
Nature genetics 20120129 3
Nuclear magnetic resonance assays allow for measurement of a wide range of metabolic phenotypes. We report here the results of a GWAS on 8,330 Finnish individuals genotyped and imputed at 7.7 million SNPs for a range of 216 serum metabolic phenotypes assessed by NMR of serum samples. We identified significant associations (P < 2.31 × 10(-10)) at 31 loci, including 11 for which there have not been previous reports of associations to a metabolic trait or disorder. Analyses of Finnish twin pairs su ...[more]