Ontology highlight
ABSTRACT:
SUBMITTER: Navarro VM
PROVIDER: S-EPMC2793332 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Navarro Victor M VM Gottsch Michelle L ML Chavkin Charles C Okamura Hiroaki H Clifton Donald K DK Steiner Robert A RA
The Journal of neuroscience : the official journal of the Society for Neuroscience 20090901 38
Kisspeptin is encoded by the Kiss1 gene, and kisspeptin signaling plays a critical role in reproduction. In rodents, kisspeptin neurons in the arcuate nucleus (Arc) provide tonic drive to gonadotropin-releasing hormone (GnRH) neurons, which in turn supports basal luteinizing hormone (LH) secretion. Our objectives were to determine whether preprodynorphin (Dyn) and neurokinin B (NKB) are coexpressed in Kiss1 neurons in the mouse and to evaluate its physiological significance. Using in situ hybrid ...[more]