Ontology highlight
ABSTRACT:
SUBMITTER: Huertas-Vazquez A
PROVIDER: S-EPMC2793376 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Huertas-Vazquez Adriana A Plaisier Christopher L CL Geng Ruishuang R Haas Blake E BE Lee Jenny J Greevenbroek Marleen M MM van der Kallen Carla C de Bruin Tjerk W A TW Taskinen Marja-Riitta MR Alagramam Kumar N KN Pajukanta Päivi P
Human genetics 20091009 1
Familial combined hyperlipidemia (FCHL) is a common lipid disorder characterized by the presence of multiple lipoprotein phenotypes that increase the risk of premature coronary heart disease. In a previous study, we identified an intragenic microsatellite marker within the protocadherin 15 (PCDH15) gene to be associated with high triglycerides (TGs) in Finnish dyslipidemic families. In this study we analyzed all four known nonsynonymous SNPs within PCDH15 in 1,268 individuals from Finnish and Du ...[more]