Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-San Martin C
PROVIDER: S-EPMC2794427 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Cell host & microbe 20081201 6
Alphaviruses infect cells via a low-pH-triggered membrane fusion reaction mediated by the class II virus fusion protein E1, an elongated molecule with three extramembrane domains (DI-III). E1 drives fusion by inserting its fusion peptide loop into the target membrane and refolding to a hairpin-like trimer in which DIII moves toward the target membrane and packs against the central trimer. Three-dimensional structures provide static pictures of prefusion and postfusion E1 but do not explain this ...[more]