Ontology highlight
ABSTRACT:
SUBMITTER: Kielian M
PROVIDER: S-EPMC3086016 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Kielian Margaret M Chanel-Vos Chantal C Liao Maofu M
Viruses 20100301 4
The study of enveloped animal viruses has greatly advanced our understanding of the general properties of membrane fusion and of the specific pathways that viruses use to infect the host cell. The membrane fusion proteins of the alphaviruses and flaviviruses have many similarities in structure and function. As reviewed here, alphaviruses use receptor-mediated endocytic uptake and low pH-triggered membrane fusion to deliver their RNA genomes into the cytoplasm. Recent advances in understanding th ...[more]