Ontology highlight
ABSTRACT:
SUBMITTER: Rand KD
PROVIDER: S-EPMC2794942 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Rand Kasper D KD Pringle Steven D SD Murphy James P JP Fadgen Keith E KE Brown Jeff J Engen John R JR
Analytical chemistry 20091201 24
Accumulating evidence suggests that solution-phase conformations of small globular proteins and large molecular protein assemblies can be preserved for milliseconds after electrospray ionization. Thus, the study of proteins in the gas phase on this time scale is highly desirable. Here we demonstrate that a traveling wave ion guide (TWIG) of a Synapt mass spectrometer offers a highly suitable environment for rapid and efficient gas-phase hydrogen/deuterium exchange (HDX). Gaseous ND(3) was introd ...[more]