Ontology highlight
ABSTRACT:
SUBMITTER: Gong B
PROVIDER: S-EPMC2795014 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Biochemistry 20091201 50
Divalent cations play critical structural and functional roles in many RNAs. While the hepatitis delta virus (HDV) ribozyme can undergo self-cleavage in the presence of molar concentrations of monovalent cations, divalent cations such as Mg(2+) are required for efficient catalysis under physiological conditions. Moreover, the cleavage reaction can be inhibited with Co(NH(3))(6)(3+), an analogue of Mg(H(2)O)(6)(2+). Here, the binding of Mg(2+) and Co(NH(3))(6)(3+) to the HDV ribozyme is studied b ...[more]