Ontology highlight
ABSTRACT:
SUBMITTER: Verheijen MH
PROVIDER: S-EPMC2795508 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Verheijen Mark H G MH Camargo Nutabi N Verdier Valerie V Nadra Karim K de Preux Charles Anne-Sophie AS Médard Jean-Jacques JJ Luoma Adrienne A Crowther Michelle M Inouye Hideyo H Shimano Hitoshi H Chen Su S Brouwers Jos F JF Helms J Bernd JB Feltri M Laura ML Wrabetz Lawrence L Kirschner Daniel D Chrast Roman R Smit August B AB
Proceedings of the National Academy of Sciences of the United States of America 20091130 50
Myelination requires a massive increase in glial cell membrane synthesis. Here, we demonstrate that the acute phase of myelin lipid synthesis is regulated by sterol regulatory element-binding protein (SREBP) cleavage activation protein (SCAP), an activator of SREBPs. Deletion of SCAP in Schwann cells led to a loss of SREBP-mediated gene expression involving cholesterol and fatty acid synthesis. Schwann cell SCAP mutant mice show congenital hypomyelination and abnormal gait. Interestingly, aging ...[more]