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In vivo selection of tumor-targeting RNA motifs.

ABSTRACT: In an effort to target the in vivo context of tumor-specific moieties, we screened a large library of nuclease-resistant RNA oligonucleotides in tumor-bearing mice to identify candidate molecules with the ability to localize to hepatic colon cancer metastases. One of the selected molecules is an RNA aptamer that binds to p68, an RNA helicase that has been shown to be upregulated in colorectal cancer.

SUBMITTER: Mi J

PROVIDER: S-EPMC2795795 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature

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In vivo selection of tumor-targeting RNA motifs.

Mi Jing J Liu Yingmiao Y Rabbani Zahid N ZN Yang Zhongguang Z Urban Johannes H JH Sullenger Bruce A BA Clary Bryan M BM

Nature chemical biology 20091129 1

In an effort to target the in vivo context of tumor-specific moieties, we screened a large library of nuclease-resistant RNA oligonucleotides in tumor-bearing mice to identify candidate molecules with the ability to localize to hepatic colon cancer metastases. One of the selected molecules is an RNA aptamer that binds to p68, an RNA helicase that has been shown to be upregulated in colorectal cancer. ...[more]

PMID: 19946274

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