Mendelian randomization in family data.
Ontology highlight
ABSTRACT:
SUBMITTER: Morris NJ
PROVIDER: S-EPMC2795944 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
Mendelian randomization in family data.
Morris Nathan J NJ Gray-McGuire Courtney C Stein Catherine M CM
BMC proceedings 20091215
The phrase "mendelian randomization" has become associated with the use of genetic polymorphisms to uncover causal relationships between phenotypic variables. The statistical methods useful in mendelian randomization are known as instrumental variable techniques. We present an approach to instrumental variable estimation that is useful in family data and is robust to the use of weak instruments. We illustrate our method to measure the causal influence of low-density lipoprotein on high-density l ...[more]
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