Associating multiple longitudinal traits with high-dimensional single-nucleotide polymorphism data: application to the Framingham Heart Study.
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ABSTRACT:
SUBMITTER: Waaijenborg S
PROVIDER: S-EPMC2795946 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
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Associating multiple longitudinal traits with high-dimensional single-nucleotide polymorphism data: application to the Framingham Heart Study.
Waaijenborg Sandra S Zwinderman Aeilko H AH
BMC proceedings 20091215
Cardiovascular diseases are associated with combinations of phenotypic traits, which are in turn caused by a combination of environmental and genetic factors. Because of the diversity of pathways that may lead to cardiovascular diseases, we examined the so-called intermediate phenotypes, which are often repeatedly measured. We developed a penalized nonlinear canonical correlation analysis to associate multiple repeatedly measured traits with high-dimensional single-nucleotide polymorphism data. ...[more]
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