Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC2796550 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Wang Hong H Westin Linda L Nong Yi Y Birnbaum Shari S Bendor Jacob J Brismar Hjalmar H Nestler Eric E Aperia Anita A Flajolet Marc M Greengard Paul P
Science (New York, N.Y.) 20091201 5959
Metabotropic glutamate receptor 5 (mGluR5) is highly expressed in the mammalian central nervous system (CNS). It is involved in multiple physiological functions and is a target for treatment of various CNS disorders, including schizophrenia. We report that Norbin, a neuron-specific protein, physically interacts with mGluR5 in vivo, increases the cell surface localization of the receptor, and positively regulates mGluR5 signaling. Genetic deletion of Norbin attenuates mGluR5-dependent stable chan ...[more]