HIV-1 infection impairs the bronchoalveolar T-cell response to mycobacteria.

ABSTRACT:

Rationale

The risk of developing active tuberculosis in persons with latent Mycobacterium tuberculosis infection is substantially increased shortly after HIV-1 seroconversion. Immune responses in the lung are important to restrict the growth of M. tuberculosis to prevent the development of disease.

Objectives

To investigate innate and adaptive immune responses to M. tuberculosis in bronchoalveolar lavage from HIV-1-infected persons without active tuberculosis.

Methods

Peripheral blood was drawn and bronchoalveolar lavage (BAL) performed on healthy, HIV-1-uninfected (n = 21) and HIV-1-infected (n = 15) adults. Growth of M. tuberculosis was assessed in monocytes and alveolar macrophages. Cytokine expression by mycobacteria-specific CD4 and CD8 T cells was measured by in

SUBMITTER: Kalsdorf B 

PROVIDER: S-EPMC2796736 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature