Ontology highlight
ABSTRACT:
SUBMITTER: Cubas RA
PROVIDER: S-EPMC3843317 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Cubas Rafael A RA Mudd Joseph C JC Savoye Anne-Laure AL Perreau Matthieu M van Grevenynghe Julien J Metcalf Talibah T Connick Elizabeth E Meditz Amie A Freeman Gordon J GJ Abesada-Terk Guillermo G Jacobson Jeffrey M JM Brooks Ari D AD Crotty Shane S Estes Jacob D JD Pantaleo Giuseppe G Lederman Michael M MM Haddad Elias K EK
Nature medicine 20130310 4
The majority of HIV-infected individuals fail to produce protective antibodies and have diminished responses to new immunizations. We report here that even though there is an expansion of follicular helper T (TFH) cells in HIV-infected individuals, the cells are unable to provide adequate B cell help. We found a higher frequency of programmed cell death ligand 1 (PD-L1)(+) germinal center B cells from lymph nodes of HIV-infected individuals suggesting a potential role for PD-1-PD-L1 interaction ...[more]