Ontology highlight
ABSTRACT:
SUBMITTER: Lavelin I
PROVIDER: S-EPMC2797363 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Lavelin Irena I Beer Avital A Kam Zvi Z Rotter Varda V Oren Moshe M Navon Ami A Geiger Benjamin B
PloS one 20091230 12
The regulated degradation of damaged or misfolded proteins, as well as down-regulation of key signaling proteins, within eukaryotic and bacterial cells is catalyzed primarily by large, ATP-dependent multimeric proteolytic complexes, termed proteasomes. Inhibition of proteasomal activity affects a wide variety of physiological and pathological processes, and was found to be particularly effective for cancer therapy. We report here on the development of a novel high throughput assay for proteasome ...[more]