Ontology highlight
ABSTRACT:
SUBMITTER: Minang JT
PROVIDER: S-EPMC2797560 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Minang Jacob T JT Trivett Matthew T MT Bolton Diane L DL Trubey Charles M CM Estes Jacob D JD Li Yuan Y Smedley Jeremy J Pung Rhonda R Rosati Margherita M Jalah Rashmi R Pavlakis George N GN Felber Barbara K BK Piatak Michael M Roederer Mario M Lifson Jeffrey D JD Ott David E DE Ohlen Claes C
Journal of immunology (Baltimore, Md. : 1950) 20091130 1
Plasma viremia decreases coincident with the appearance of virus-specific CD8(+) T cells during acute HIV or SIV infection. This finding, along with demonstrations of viral mutational escape from CD8(+) T cell responses and transient increase in plasma viremia after depletion of CD8(+) T cells in SIV-infected monkeys strongly suggest a role for CD8(+) T cells in controlling HIV/SIV. However, direct quantitative or qualitative correlates between CD8(+) T cell activity and virus control have not b ...[more]