Ontology highlight
ABSTRACT:
SUBMITTER: Nakanishi K
PROVIDER: S-EPMC2797963 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Nakanishi Koji K Shima Yukio Y
Diabetes care 20091016 1
<h4>Objective</h4>To identify type 1 diabetes-susceptible HLA DR-DQ haplotypes using tag single nucleotide polymorphisms (SNPs) and to estimate the disease risk using these tag SNPs.<h4>Research design and methods</h4>Five tag SNPs were typed in a total of 211 Japanese subjects including 201 patients with type 1 diabetes who had already been typed for HLA-DRB1, -DQA1, and -DQB1 alleles and 300 control subjects.<h4>Results</h4>Tag SNP rs2395185 captured haplotypes involving all DR4 specificities ...[more]