Dataset Information
The HLA-B 3906 allele imparts a high risk of diabetes only on specific HLA-DR/DQ haplotypes.
Ontology highlight
ABSTRACT: Aims/hypothesis
We investigated the risk associated with HLA-B*39 alleles in the context of specific HLA-DR/DQ haplotypes.Methods
We studied a readily available dataset from the Type 1 Diabetes Genetics Consortium that consists of 2,300 affected sibling pair families genotyped for both HLA alleles and 2,837 single nucleotide polymorphisms across the major histocompatibility complex region.Results
The B*3906 allele significantly enhanced the risk of type 1 diabetes when present on specific HLA-DR/DQ haplotypes (DRB1 0801-DQB1 0402: p?=?1.6?×?10(-6), OR 25.4; DRB1 0101-DQB1 0501: p?=?4.9?×?10(-5), OR 10.3) but did not enhance the risk of DRB1 0401-DQB1 0302 haplotypes. In addition, the B 3901 allele enhanced risk on the DRB1 1601-DQB1 0502 haplotype (p?=?3.7?×?10(-3), OR 7.2).Conclusions/interpretation
These associations indicate that the B 39 alleles significantly increase risk when present on specific HLA-DR/DQ haplotypes, and HLA-B typing in concert with specific HLA-DR/DQ genotypes should facilitate genetic prediction of type 1 diabetes, particularly in a research setting.
SUBMITTER: Baschal EE
PROVIDER: S-EPMC3110277 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Publications
The HLA-B 3906 allele imparts a high risk of diabetes only on specific HLA-DR/DQ haplotypes.
Diabetologia 20110501 7
<h4>Aims/hypothesis</h4>We investigated the risk associated with HLA-B*39 alleles in the context of specific HLA-DR/DQ haplotypes.<h4>Methods</h4>We studied a readily available dataset from the Type 1 Diabetes Genetics Consortium that consists of 2,300 affected sibling pair families genotyped for both HLA alleles and 2,837 single nucleotide polymorphisms across the major histocompatibility complex region.<h4>Results</h4>The B*3906 allele significantly enhanced the risk of type 1 diabetes when pr ...[more]