Ontology highlight
ABSTRACT:
SUBMITTER: Voyich JM
PROVIDER: S-EPMC2799113 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Voyich Jovanka M JM Vuong Cuong C DeWald Mark M Nygaard Tyler K TK Kocianova Stanislava S Griffith Shannon S Jones Jennifer J Iverson Courtney C Sturdevant Daniel E DE Braughton Kevin R KR Whitney Adeline R AR Otto Michael M DeLeo Frank R FR
The Journal of infectious diseases 20090601 11
Methicillin-resistant Staphylococcus aureus is problematic both in hospitals and in the community. Currently, we have limited understanding of mechanisms of innate immune evasion used by S. aureus. To that end, we created an isogenic deletion mutant in strain MW2 (USA400) of the saeR/S 2-component gene regulatory system and studied its role in mouse models of pathogenesis and during human neutrophil interaction. In this study, we demonstrate that saeR/S plays a distinct role in S. aureus pathoge ...[more]