Ontology highlight
ABSTRACT:
SUBMITTER: Samudio I
PROVIDER: S-EPMC2799198 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Samudio Ismael I Harmancey Romain R Fiegl Michael M Kantarjian Hagop H Konopleva Marina M Korchin Borys B Kaluarachchi Kumar K Bornmann William W Duvvuri Seshagiri S Taegtmeyer Heinrich H Andreeff Michael M
The Journal of clinical investigation 20091221 1
The traditional view is that cancer cells predominately produce ATP by glycolysis, rather than by oxidation of energy-providing substrates. Mitochondrial uncoupling--the continuing reduction of oxygen without ATP synthesis--has recently been shown in leukemia cells to circumvent the ability of oxygen to inhibit glycolysis, and may promote the metabolic preference for glycolysis by shifting from pyruvate oxidation to fatty acid oxidation (FAO). Here we have demonstrated that pharmacologic inhibit ...[more]