Ontology highlight
ABSTRACT:
SUBMITTER: Nowick K
PROVIDER: S-EPMC2799715 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Nowick Katja K Gernat Tim T Almaas Eivind E Stubbs Lisa L
Proceedings of the National Academy of Sciences of the United States of America 20091210 52
Humans differ from other primates by marked differences in cognitive abilities and a significantly larger brain. These differences correlate with metabolic changes, as evidenced by the relative up-regulation of energy-related genes and metabolites in human brain. While the mechanisms underlying these evolutionary changes have not been elucidated, altered activities of key transcription factors (TFs) could play a pivotal role. To assess this possibility, we analyzed microarray data from five tiss ...[more]