Ontology highlight
ABSTRACT:
SUBMITTER: Chen TS
PROVIDER: S-EPMC2800221 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Chen Tian Sheng TS Lai Ruenn Chai RC Lee May May MM Choo Andre Boon Hwa AB Lee Chuen Neng CN Lim Sai Kiang SK
Nucleic acids research 20091022 1
Intercellular exchange of protein and RNA-containing microparticles is an increasingly important mode of cell-cell communication. Here we investigate if mesenchymal stem cells (MSCs) known for secreting therapeutic paracrine factors also secrete RNA-containing microparticles. We observed that human embryonic stem cell (hESC)-derived MSC conditioned medium contained small RNAs (less than 300 nt) encapsulated in cholesterol-rich phospholipid vesicles as evidenced by their RNase sensitivity only in ...[more]