Ontology highlight
ABSTRACT:
SUBMITTER: Yu M
PROVIDER: S-EPMC2800995 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Yu Ming M Riva Laura L Xie Huafeng H Schindler Yocheved Y Moran Tyler B TB Cheng Yong Y Yu Duonan D Hardison Ross R Weiss Mitchell J MJ Orkin Stuart H SH Bernstein Bradley E BE Fraenkel Ernest E Cantor Alan B AB
Molecular cell 20091101 4
The transcription factor GATA-1 is required for terminal erythroid maturation and functions as an activator or repressor depending on gene context. Yet its in vivo site selectivity and ability to distinguish between activated versus repressed genes remain incompletely understood. In this study, we performed GATA-1 ChIP-seq in erythroid cells and compared it to GATA-1-induced gene expression changes. Bound and differentially expressed genes contain a greater number of GATA-binding motifs, a highe ...[more]