Ontology highlight
ABSTRACT:
SUBMITTER: Pal S
PROVIDER: S-EPMC327128 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
Pal Saumen S Cantor Alan B AB Johnson Kirby D KD Moran Tyler B TB Boyer Meghan E ME Orkin Stuart H SH Bresnick Emery H EH
Proceedings of the National Academy of Sciences of the United States of America 20040108 4
Coregulator recruitment by DNA-bound factors results in chromatin modification and protein-protein interactions, which regulate transcription. However, the mechanism by which the Friend of GATA (FOG) coregulator mediates GATA factor-dependent transcription is unknown. We showed previously that GATA-1 replaces GATA-2 at an upstream region of the GATA-2 locus, and that this GATA switch represses GATA-2. Genetic complementation analysis in FOG-1-null hematopoietic precursors revealed that FOG-1 is ...[more]