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Rapid multistep synthesis of 1,2,4-oxadiazoles in a single continuous microreactor sequence.

ABSTRACT: A general method for the synthesis of bis-substituted 1,2,4-oxadiazoles from readily available arylnitriles and activated carbonyls in a single continuous microreactor sequence is described. The synthesis incorporates three sequential microreactors to produce 1,2,4-oxadiazoles in approximately 30 min in quantities (40-80 mg) sufficient for full characterization and rapid library supply.

SUBMITTER: Grant D

PROVIDER: S-EPMC2801056 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature

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Rapid multistep synthesis of 1,2,4-oxadiazoles in a single continuous microreactor sequence.

Grant Daniel D Dahl Russell R Cosford Nicholas D P ND

The Journal of organic chemistry 20080808 18

A general method for the synthesis of bis-substituted 1,2,4-oxadiazoles from readily available arylnitriles and activated carbonyls in a single continuous microreactor sequence is described. The synthesis incorporates three sequential microreactors to produce 1,2,4-oxadiazoles in approximately 30 min in quantities (40-80 mg) sufficient for full characterization and rapid library supply. ...[more]

PMID: 18687005

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