Ontology highlight
ABSTRACT:
SUBMITTER: Buas MF
PROVIDER: S-EPMC2801253 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Buas Matthew F MF Kabak Shara S Kadesch Tom T
The Journal of biological chemistry 20091116 2
Members of the Hey family of transcriptional repressors are basic helix-loop-helix proteins that are thought to act downstream of Notch in diverse tissues. Although forced expression of Hey1, a target of Notch in myoblasts, is sufficient to recapitulate inhibitory effects of the pathway on differentiation, how Hey1 interferes with myogenic transcription has not been fully elucidated. We provide multiple lines of evidence that Hey1 does not target the intrinsic transcriptional activity of the ske ...[more]