Ontology highlight
ABSTRACT:
SUBMITTER: Scroyen I
PROVIDER: S-EPMC4697848 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Scroyen Ilse I Bauters Dries D Vranckx Christine C Lijnen H Roger HR
PloS one 20151231 12
<h4>Background</h4>Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) belongs to the steroid/thyroid hormone receptor superfamily and may contribute to the pathogenesis of obesity. It has not conclusively been established, however, whether its role is pro- or anti-adipogenic.<h4>Methods and results</h4>Gene silencing of Coup-tfII in 3T3-F442A preadipocytes resulted in enhanced differentiation into mature adipocytes. This was associated with upregulation of the Notch signalin ...[more]