Ontology highlight
ABSTRACT:
SUBMITTER: Duan L
PROVIDER: S-EPMC2801280 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Duan Lei L Chen Gengsheng G Virmani Sumeet S Ying GuoGuang G Raja Srikumar M SM Chung Byung Min BM Rainey Mark A MA Dimri Manjari M Ortega-Cava Cesar F CF Zhao Xiangshan X Clubb Robert J RJ Tu Chun C Reddi Alagarsamy L AL Naramura Mayumi M Band Vimla V Band Hamid H
The Journal of biological chemistry 20091013 2
Non-malignant mammary epithelial cells (MECs) undergo acinar morphogenesis in three-dimensional Matrigel culture, a trait that is lost upon oncogenic transformation. Rho GTPases are thought to play important roles in regulating epithelial cell-cell junctions, but their contributions to acinar morphogenesis remain unclear. Here we report that the activity of Rho GTPases is down-regulated in non-malignant MECs in three-dimensional culture with particular suppression of Rac1 and Cdc42. Inducible ex ...[more]