Ontology highlight
ABSTRACT:
SUBMITTER: Mohanty S
PROVIDER: S-EPMC4577300 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Mohanty Smita S Kennedy Eileen J EJ Herberg Friedrich W FW Hui Raymond R Taylor Susan S SS Langsley Gordon G Kannan Natarajan N
Biochimica et biophysica acta 20150403 10 Pt B
Many cellular functions in eukaryotic pathogens are mediated by the cyclic nucleotide binding (CNB) domain, which senses second messengers such as cyclic AMP and cyclic GMP. Although CNB domain-containing proteins have been identified in many pathogenic organisms, an incomplete understanding of how CNB domains in pathogens differ from other eukaryotic hosts has hindered the development of selective inhibitors for CNB domains associated with infectious diseases. Here, we identify and classify CNB ...[more]