Ontology highlight
ABSTRACT:
SUBMITTER: Kii I
PROVIDER: S-EPMC2804360 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Kii Isao I Nishiyama Takashi T Li Minqi M Matsumoto Ken-Ichi K Saito Mitsuru M Amizuka Norio N Kudo Akira A
The Journal of biological chemistry 20091103 3
Extracellular matrix (ECM) underlies a complicated multicellular architecture that is subjected to significant forces from mechanical environment. Although various components of the ECM have been enumerated, mechanisms that evolve the sophisticated ECM architecture remain to be addressed. Here we show that periostin, a matricellular protein, promotes incorporation of tenascin-C into the ECM and organizes a meshwork architecture of the ECM. We found that both periostin null mice and tenascin-C nu ...[more]