Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC2951554 | biostudies-other | 2010 Oct
REPOSITORIES: biostudies-other
Chen Jian J Joon Lee Hyun H Jakovcevski Igor I Shah Ronak R Bhagat Neha N Loers Gabriele G Liu Hsing-Yin HY Meiners Sally S Taschenberger Grit G Kügler Sebastian S Irintchev Andrey A Schachner Melitta M
Molecular therapy : the journal of the American Society of Gene Therapy 20100706 10
Tenascin-C (TNC), a major component of the extracellular matrix, is strongly upregulated after injuries of the central nervous system (CNS) but its role in tissue repair is not understood. Both regeneration promoting and inhibiting roles of TNC have been proposed considering its abilities to both support and restrict neurite outgrowth in vitro. Here, we show that spontaneous recovery of locomotor functions after spinal cord injury is impaired in adult TNC-deficient (TNC(-/-)) mice in comparison ...[more]