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A tyramine-gated chloride channel coordinates distinct motor programs of a Caenorhabditis elegans escape response.


ABSTRACT: A key feature of escape responses is the fast translation of sensory information into a coordinated motor output. In C. elegans, anterior touch initiates a backward escape response in which lateral head movements are suppressed. Here, we show that tyramine inhibits head movements and forward locomotion through the activation of a tyramine-gated chloride channel, LGC-55. lgc-55 mutant animals have defects in reversal behavior and fail to suppress head oscillations in response to anterior touch. lgc-55 is expressed in neurons and muscle cells that receive direct synaptic inputs from tyraminergic motor neurons. Therefore, tyramine can act as a classical inhibitory neurotransmitter. Activation of LGC-55 by tyramine coordinates the output of two distinct motor programs, locomotion and head movements that are critical for a C. elegans escape response.

SUBMITTER: Pirri JK 

PROVIDER: S-EPMC2804440 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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A tyramine-gated chloride channel coordinates distinct motor programs of a Caenorhabditis elegans escape response.

Pirri Jennifer K JK   McPherson Adam D AD   Donnelly Jamie L JL   Francis Michael M MM   Alkema Mark J MJ  

Neuron 20090501 4


A key feature of escape responses is the fast translation of sensory information into a coordinated motor output. In C. elegans, anterior touch initiates a backward escape response in which lateral head movements are suppressed. Here, we show that tyramine inhibits head movements and forward locomotion through the activation of a tyramine-gated chloride channel, LGC-55. lgc-55 mutant animals have defects in reversal behavior and fail to suppress head oscillations in response to anterior touch. l  ...[more]

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