Ontology highlight
ABSTRACT:
SUBMITTER: Pirri JK
PROVIDER: S-EPMC2804440 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Pirri Jennifer K JK McPherson Adam D AD Donnelly Jamie L JL Francis Michael M MM Alkema Mark J MJ
Neuron 20090501 4
A key feature of escape responses is the fast translation of sensory information into a coordinated motor output. In C. elegans, anterior touch initiates a backward escape response in which lateral head movements are suppressed. Here, we show that tyramine inhibits head movements and forward locomotion through the activation of a tyramine-gated chloride channel, LGC-55. lgc-55 mutant animals have defects in reversal behavior and fail to suppress head oscillations in response to anterior touch. l ...[more]