Ontology highlight
ABSTRACT:
SUBMITTER: Bai X
PROVIDER: S-EPMC7340503 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Bai Xiaofei X Bouffard Jeff J Lord Avery A Brugman Katherine K Sternberg Paul W PW Cram Erin J EJ Golden Andy A
eLife 20200603
PIEZO1 and PIEZO2 are newly identified mechanosensitive ion channels that exhibit a preference for calcium in response to mechanical stimuli. In this study, we discovered the vital roles of <i>pezo-1</i>, the sole <i>PIEZO</i> ortholog in <i>Caenorhabditiselegans,</i> in regulating reproduction. A number of deletion alleles, as well as a putative gain-of-function mutant, of PEZO-1 caused a severe reduction in brood size. In vivo observations showed that oocytes undergo a variety of transit defec ...[more]