Multiple recombinants in two dengue virus, serotype-2 isolates from patients from Oaxaca, Mexico.

ABSTRACT:

Background

Dengue (DEN) is a serious cause of mortality and morbidity in the world including Mexico, where the infection is endemic. One of the states with the highest rate of dengue cases is Oaxaca. The cause of DEN is a positive-sense RNA virus, the dengue virus (DENV) that evolves rapidly increasing its variability due to the absence of a repair mechanism that leads to approximately one mutational event per genome replication; which results in enhancement of viral adaptation, including the escape from host immune responses. Additionally, recombination may play a role in driving the evolution of DENV, which may potentially affect virulence and cause host tropism changes. Recombination in DENV has not been described in Mexican strains, neither has been described the relevance in v

SUBMITTER: Perez-Ramirez G 

PROVIDER: S-EPMC2804599 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature