Ontology highlight
ABSTRACT:
SUBMITTER: Semizarov D
PROVIDER: S-EPMC28056 | biostudies-literature | 1998 Dec
REPOSITORIES: biostudies-literature
Semizarov D D Glesne D D Laouar A A Schiebel K K Huberman E E
Proceedings of the National Academy of Sciences of the United States of America 19981201 26
To identify genes involved in macrophage development, we used the differential display technique and compared the gene expression profiles for human myeloid HL-60 leukemia cell lines susceptible and resistant to macrophage maturation. We identified a gene coding for a protein kinase, protein kinase X (PRKX), which was expressed in the maturation-susceptible, but not in the resistant, cell line. The expression of the PRKX gene was found to be induced during monocyte, macrophage, and granulocyte m ...[more]